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Two-organ on-a-chip device reproduces acetaminophen metabolism

Mahler, G.J., Esch M.B., Shuler, M.L. “Characterization of a Gastrointestinal Tract Microscale Cell Culture Analog Used to Predict Drug Toxicity ”, Biotechnology & Bioengineering, 2009,...
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LOC 2014: A two-organ system is more sensitive to damage by nanoparticles than single tissues in isolation

Mandy B. Esch, Gretchen J. Mahler, Tracy Stokol, Michael L. Shuler, Body-on-a-Chip simulation with gastrointestinal and liver tissue suggests that ingested nanoparticles have the potential...
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BMES 2014 reviewer’s choice award: Primary liver cells elevate metabolism in pumpless microfluidic device

Mandy B. Esch, Jean Prot, Ying Wang, Paula Miller, Micheal L. Shuler Introduction: Toxicity to the liver is one of the most common reasons...
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How body-on-a-chip devices can help foster drug development: an outline of strategies

Microphysiologic Cell Culture Systems are microfluidic platforms on which multiple in vitro tissues can communicate with each other via soluble metabolites that re-circulate through a...
3D tissue scaffold

3D tissue scaffold for on-chip gut: microfabrication and integration into fluidic cell culture platform

Esch, M.B., Sung, J.H., Yang, J. Yu, J., March, J.C., Shuler, M.L. “On Chip Porous Polymer Membranes for Integration of Gastrointestinal Tract Epithelium with...
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Nature Nanotech: nanoparticles influence iron uptake and change the sizes of macrovilli in the gut

Gretchen J. Mahler, Mandy B. Esch, Elad Tako, Shivaun D. Archer, Raymond P. Glahn, Michael L. Shuler, Oral Exposure to Nanoparticles Affects Essential Nutrient Absorption.  Nature Nanotechnology, 2012, 7,...
HUVEC grown within a microfluidic channel

Tissue Engineering A: 50 micrometer in vitro microvasculature (endothelial lining) establishes adherents junctions even on the sidewalls of channels

Esch, M.B., Post, D., Shuler, M.L., Stokol, T. “Characterization of Small Diameter In Vitro Endothelial Linings of the Microvasculature,” Tissue Engineering A, 2011, 17, 2965-2971...
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Small vessels fully lined with endothelial cells can be used to study circulatory diseases

Mandy B. Esch, David J. Post, Michael L. Shuler, Tracy Stokol, Characterization of Small Diameter In Vitro Endothelial Linings of the Microvasculature. Tissue Engineering A, 2011,...
Crypto

Analytical Chemistry: Microfluidic sensor for sensing heat-shock mRNA of Cryptosporidium parvum

Esch, M.B.; Locascio, L.; Tarlov, M.J.; Durst, R.A. “Detection of Viable Cryptosporidium parvum in a Microfluidic Chip”, Analytical Chemistry, 2001, 73 (13), 2952-2958. In this...
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Pittcon: Paper-based microfluidics for the detection of C. parvum mRNA in 30 min

Esch, M.B.; Bäumner, A.; Durst, R.A. “Rapid Visual Detection of Viable Cryptosporidium parvum on Test Strips using Oligonucleotide-tagged Liposomes” Analytical Chemistry, 2001, 73(13), 3162-3167 Paper-based...