Body-on-a-Chip Research

Drug and toxicity testing with body-on-a-chip systems: 

High quality, in vitro screening tools are essential in identifying promising compounds during drug development. Tests with currently used cell-based assays only provide an indication of a compound’s potential therapeutic benefits to the target tissue, but not the whole body. Data obtained with animal models often can not be extrapolated to humans. Multi-compartment microfluidic based devices, particularly those that are physical representations of ….     more

 

Microfabricated 3D scaffolds for tissue engineering 

A physiologically correct, on-chip, first pass metabolism model of oral absorption of drugs and environmental toxicants requires a microfluidic cell culture systems with three dimensional, multi cell-type cultures that replicate in vivo cell morphologies and structure. “First pass metabolism” refers to…     more

 

In vitro microvasculature for studying cancer metastasis and angiogenesis 

In vitro microvascular endothelial linings can be used to investigate biophysical and molecular mechanisms that play a role in circulatory disease phenomena such as inflammation, responses of the immune system and cancer cell attachment to the endothelium. In vivo, endothelial cells grow on…   more

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