Two-organ on-a-chip device reproduces acetaminophen metabolism

gi1_00Mahler, G.J., Esch M.B., Shuler, M.L. “Characterization of a Gastrointestinal Tract Microscale Cell Culture Analog Used to Predict Drug Toxicity ”, Biotechnology & Bioengineering, 2009, 104(1), 193-205.

The oral uptake of acetaminophen was simulated with a two-organ microfluidic cell culture platform. The platform contained tissues that mimicked the GI tract epithelium and the liver. Concentrations of metabolites of acetaminophen in the cell culture medium were monitored over 24 hours, revealing that the system was capable of reproducing the uptake and first pass metabolism of acetaminophen.

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